反应详情

In a similar manner as described for example 49 (step 1), 2.9 g of 3-[-1-(2-fluorophenyl)ethoxy]-5-[6-(hydroxymethyl)-3H-imidazo[4,5-c]pyridin-3-yl]thiophene-2-carboxamide, 1.53 g of methanesulfonyl chloride, and 1.42 g of triethylamine in 70 ml dichloromethane give (3-{5-carbamoyl-4-[-1-(2-fluorophenyl)ethoxy]-2-thienyl}-3H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate as crude material that is used for step 2 without further purification.