Ammonia → HCID 68768875, compound

HRID 2391669Notes

Reaction equation

HRID 2391669 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[N:15]=[CH:14][C:13]2[N:16]=[CH:17][N:18]([C:19]3[S:23][C:22]([C:24]([O:26]C)=O)=[C:21]([O:28][CH:29]([C:31]4[CH:36]=[CH:35][C:34]([C:37]#[N:38])=[CH:33][C:32]=4[Cl:39])[CH3:30])[CH:20]=3)[C:12]=2[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH3:40]>CO>[Si:1]([O:8][CH2:9][C:10]1[N:15]=[CH:14][C:13]2[N:16]=[CH:17][N:18]([C:19]3[S:23][C:22]([C:24]([NH2:40])=[O:26])=[C:21]([O:28][CH:29]([C:31]4[CH:36]=[CH:35][C:34]([C:37]#[N:38])=[CH:33][C:32]=4[Cl:39])[CH3:30])[CH:20]=3)[C:12]=2[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68768686HCID 68768686, compound

Product 1

HCID 68768875HCID 68768875, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
125 °C

Procedure

1.50 g of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-[-1-(2-chloro-4-cyanophenyl)ethoxy]thiophene-2-carboxylate are dissolved in 60 ml of a 7 N solution of ammonia in methanol. The reaction mixture is stirred for 5 hours at 125° C. under microwave radiation.

Sources & evidence

ORD record
ord-9b3a4a9ee4db43f1bc2b1d0849e3e618
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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