Potassium Carbonate → Methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate

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Reaction Steps

In a similar manner as described for example B3, 2.08 g of an isomeric mixture of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-hydroxythiophene-2-carboxylate and methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate (example C3) and 0.82 g of K2CO3 and 1.42 g of 1-(bromomethyl)-2-(trifluoromethyl)benzene in 15 ml N,N-dimethylformamide yield compound B2a and compound B2b.

Provenance & Evidence