HRID2391683

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID123057

1-(Bromomethyl)-2-(trifluoromethyl)benzene

C8H6BrF3

结构：COC(=O)c1sc(-n2cnc3cc(CO[Si](C)(C)C(C)(C)C)ncc32)cc1O

HCID68766004

未命名化合物

结构：COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1O

HCID68766707

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1OCc1ccccc1C(F)(F)F

HCID68766097

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In a similar manner as described for example B3, 2.08 g of an isomeric mixture of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-hydroxythiophene-2-carboxylate and methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate (example C3) and 0.82 g of K2CO3 and 1.42 g of 1-(bromomethyl)-2-(trifluoromethyl)benzene in 15 ml N,N-dimethylformamide yield compound B2a and compound B2b.

WORKUP

后处理

customyield compound B2a

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-437aa8611f7448f295b7a4d33439fed3
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273890B2
来源说明: uspto-grants-2012_09

反应 SMILES

[Si](OCC1N=CC2N(C3SC(C(OC)=O)=C(O)C=3)C=NC=2C=1)(C(C)(C)C)(C)C.[Si:29]([O:36][CH2:37][C:38]1[N:43]=[CH:42][C:41]2[N:44]=[CH:45][N:46]([C:47]3[S:51][C:50]([C:52]([O:54][CH3:55])=[O:53])=[C:49]([OH:56])[CH:48]=3)[C:40]=2[CH:39]=1)([C:32]([CH3:35])([CH3:34])[CH3:33])([CH3:31])[CH3:30].C([O-])([O-])=O.[K+].[K+].Br[CH2:64][C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][C:66]=1[C:71]([F:74])([F:73])[F:72]>CN(C)C=O>[Si:29]([O:36][CH2:37][C:38]1[N:43]=[CH:42][C:41]2[N:44]=[CH:45][N:46]([C:47]3[S:51][C:50]([C:52]([O:54][CH3:55])=[O:53])=[C:49]([O:56][CH2:64][C:65]4[CH:70]=[CH:69][CH:68]=[CH:67][C:66]=4[C:71]([F:72])([F:73])[F:74])[CH:48]=3)[C:40]=2[CH:39]=1)([C:32]([CH3:33])([CH3:34])[CH3:35])([CH3:30])[CH3:31]