HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 68767170, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-2-(trifluoromethyl)benzene | HCID 123057 | — |
| Reactant | HCID 68766620 | HCID 68766620 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68767170 | HCID 68767170 | — |
Reaction Steps
In a similar manner as described for example B8, 1.03 g of methyl 3-hydroxy-5-{6-[(2-morpholin-4-ylethyl)carbamoyl]-1H-imidazo[4,5-c]pyridin-1-yl}thiophene-2-carboxylate (compound C4), 326 mg K2CO3 and 683 mg 1-(bromomethyl)-2-(trifluoromethyl)benzene in 11 ml of N,N-dimethylformamide yield the title compound as crude material. The compound was used for the next step (examples 5 and 11) without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273890B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c161dc45e9994d829fb3e91a0d4c16ea |
| Source note | uspto-grants-2012_09 |