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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391690Generated: October 30, 2026

Potassium Carbonate → HCID 68767170, compound

https://huagongshe.com/reaction/2391690

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant1-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 123057—
ReactantHCID 68766620HCID 68766620—
SolventDimethylformamideHCID 6228—
ProductHCID 68767170HCID 68767170—

Reaction Steps

In a similar manner as described for example B8, 1.03 g of methyl 3-hydroxy-5-{6-[(2-morpholin-4-ylethyl)carbamoyl]-1H-imidazo[4,5-c]pyridin-1-yl}thiophene-2-carboxylate (compound C4), 326 mg K2CO3 and 683 mg 1-(bromomethyl)-2-(trifluoromethyl)benzene in 11 ml of N,N-dimethylformamide yield the title compound as crude material. The compound was used for the next step (examples 5 and 11) without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273890B2
Source datasetuspto-grants-2012_09
ORD IDord-c161dc45e9994d829fb3e91a0d4c16ea
Source noteuspto-grants-2012_09