Potassium Carbonate → HCID 68767170, compound

HRID 2391690Notes

Reaction equation

HRID 2391690 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([N:7]2[C:15]3[CH:14]=[C:13]([C:16](=[O:26])[NH:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)[N:12]=[CH:11][C:10]=3[N:9]=[CH:8]2)[S:4][C:3]=1[C:27]([O:29][CH3:30])=[O:28].C([O-])([O-])=O.[K+].[K+].Br[CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[C:45]([F:48])([F:47])[F:46]>CN(C)C=O>[N:20]1([CH2:19][CH2:18][NH:17][C:16]([C:13]2[N:12]=[CH:11][C:10]3[N:9]=[CH:8][N:7]([C:5]4[S:4][C:3]([C:27]([O:29][CH3:30])=[O:28])=[C:2]([O:1][CH2:38][C:39]5[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=5[C:45]([F:46])([F:47])[F:48])[CH:6]=4)[C:15]=3[CH:14]=2)=[O:26])[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 68766620HCID 68766620, compound2×

Product 1

HCID 68767170HCID 68767170, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner as described for example B8, 1.03 g of methyl 3-hydroxy-5-{6-[(2-morpholin-4-ylethyl)carbamoyl]-1H-imidazo[4,5-c]pyridin-1-yl}thiophene-2-carboxylate (compound C4), 326 mg K2CO3 and 683 mg 1-(bromomethyl)-2-(trifluoromethyl)benzene in 11 ml of N,N-dimethylformamide yield the title compound as crude material. The compound was used for the next step (examples 5 and 11) without further purification.

Sources & evidence

ORD record
ord-c161dc45e9994d829fb3e91a0d4c16ea
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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