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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391703Generated: October 30, 2026

Potassium Carbonate → methyl 3-{[2-(difluoromethoxy)benzyl]oxy}-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate

https://huagongshe.com/reaction/2391703

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant1-(Bromomethyl)-2-(difluoromethoxy)benzeneHCID 2736998—
Reactantmethyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylateHCID 68766294—
SolventDimethylformamideHCID 6228—
Productmethyl 3-{[2-(difluoromethoxy)benzyl]oxy}-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylateHCID 68766710—

Reaction Steps

In a similar manner as described for example B18, 207.7 mg of 2-(difluoromethoxy)benzyl bromide, 200 mg of methyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate, 110.9 mg of potassium carbonate in 6 ml anhydrous DMF yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273890B2
Source datasetuspto-grants-2012_09
ORD IDord-37f65ee285b040309eb499e8707fdadc
Source noteuspto-grants-2012_09