Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate → HCID 68766230, compound

HRID 2391728Notes

Reaction equation

HRID 2391728 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:13]=[CH:12][C:11]2[N:14]=[CH:15][NH:16][C:10]=2[CH:9]=1)=[O:7].Cl[C:18]1([C:24]([O:26][CH3:27])=[O:25])[C:22](=[O:23])[CH:21]=[CH:20][S:19]1>C(Cl)(Cl)Cl>[OH:23][C:22]1[CH:21]=[C:20]([N:16]2[C:10]3[CH:9]=[C:8]([C:6](=[O:7])[NH:5][CH2:4][CH2:3][O:2][CH3:1])[N:13]=[CH:12][C:11]=3[N:14]=[CH:15]2)[S:19][C:18]=1[C:24]([O:26][CH3:27])=[O:25]

Participants

4

Reactant 2

HCID 15588102Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylateHCID 178495987HCID 178495987, compound

Product 1

HCID 68766230HCID 68766230, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In a similar manner as described for example C3, 1.81 g of 1H-imidazo[4,5-c]pyridine-6-carboxylic acid (2-methoxy-ethyl)-amide and 1.27 g of methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate in 300 ml chloroform yield the title compound which was used for the next step without further purification (example B8).

Sources & evidence

ORD record
ord-04e0f452b8a6484aad4092f59c98cd29
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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