Hydrochloric Acid → HCID 57826478, compound

HRID 2391957Notes

Reaction equation

HRID 2391957 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH:13]([NH:23]C(=O)OC(C)(C)C)[C:14]([CH3:22])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:15].Cl>C(Cl)(Cl)Cl.CO.O1CCOCC1>[NH2:23][CH:13]([C:14]([CH3:22])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:15])[CH2:12][N:3]1[C:4](=[O:11])[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]1=[O:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57826738HCID 57826738, compound

Product 1

HCID 57826478HCID 57826478, compound

Reagents, catalysts & solvents 2

HCID 312751,4-DioxaneSolventHCID 21584188Chloroform methanolSolvent

Procedure

To a solution of 1,1-dimethylethyl {1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-methyl-2-phenylpropyl}carbamate (723 mg, 1.77 mmol) in CHCl3:MeOH (10:1, 55 mL) at RT was added 4M HCl in dioxane (10 mL). After stirring for 3 h at RT, the reaction solution was concentrated to a white solid (quant.): LCMS (ES) m/z 309 (M+H)+.

Workup

  1. concentrationthe reaction solution was concentrated to a white solid (quant.)

Sources & evidence

ORD record
ord-965075e1bf0a430cb5f7d8eb606e9aef
Source dataset
uspto-grants-2012_09
Patent number
US08273782B2

Reaction notes

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