反应详情

A mixture of sulphanilamide (20 g, 0.166 mol), benzoyl cyanamide (34 g, 0.33 mmol) in ethanol (60 ml) and concentrated hydrochloric acid (11 ml) was heated on a steam bath until the solvent had evaporated. Water was added and the mixture heated at reflux for 5 minutes. Sodium hydroxide (14.4 g) was added and the mixture heated at reflux. The mixture was allowed to cool and was adjusted to pH2 with hydrochloric acid and the precipitated solid removed by filtration. The filtrate was neutralised and the solvent removed by evaporation. The residue was recrystallized from water to give crude title product. m/z: 215 [MH]+.

1. temperaturewas heated on a steam bath until the solvent
2. customhad evaporated
3. additionWater was added
4. temperaturethe mixture heated
5. temperatureat reflux for 5 minutes
6. additionSodium hydroxide (14.4 g) was added
7. temperaturethe mixture heated
8. temperatureat reflux
9. temperatureto cool
10. customthe precipitated solid removed by filtration
11. customthe solvent removed by evaporation
12. customThe residue was recrystallized from water