N,N-Dimethyl-N'-t-butyloxycarbonyl-N'-(5-amino-2-methoxyphenyl)ethylenediamine → N-[3-[N-(2-Dimethylaminoethyl)-N-t-butyloxycarbonylamino]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	N,N-Dimethyl-N'-t-butyloxycarbonyl-N'-(5-amino-2-methoxyphenyl)ethylenediamine	HCID 10828698	—
Reactant	4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzoic Acid	HCID 11130168	—
Product	N-[3-[N-(2-Dimethylaminoethyl)-N-t-butyloxycarbonylamino]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide	HCID 10674839	—

Reaction Steps

The title compound was prepared from N,N-dimethyl-N'-t-butyloxycarbonyl-N'-(5-amino-2-methoxyphenyl)ethylenediamine (D21, 0.37 g, 0.0012 mole) and 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-carboxylic acid (EP 0533268 A1) (0.34 g, 0.0012 mol) using the method of Example 1 (0.40 g, 57%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05801170
Source dataset	uspto-grants-1998_09
ORD ID	ord-9b1db326f46a4597a0e19a845179ca7e
Source note	uspto-grants-1998_09