反应详情

A solution of 3-(2dimethylaminoethoxy)-4chloronitrobenzene (D57) (295 mg) in ethanol (5 ml) was heated to 60° C. and treated dropwise with a solution of stannous chloride (0.82 g) in concentrated hydrochloric acid (1.5 ml) with stiring. After heating to reflux for 1/2 h, the reaction mixture was cooled, diluted with water and basified with 40% NaOH, then extracted into dichloromethane. The dried (Na2SO4) organic phase was evaporated under reduced pressure to give the title compound as a yellow oil. (221 mg, 85%).

1. temperatureAfter heating
2. temperatureto reflux for 1/2 h
3. temperaturethe reaction mixture was cooled
4. extractionextracted into dichloromethane
5. dry with materialThe dried (Na2SO4) organic phase
6. customwas evaporated under reduced pressure