2-Chloro-5-nitrophenol → 4'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxylic acid

HRID 2392655Notes

Reaction equation

HRID 2392655 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10](Br)=[CH:9][CH:8]=2)[N:3]=1.B([C:17]1[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=1)(O)O.ClC1C=CC([N+]([O-])=O)=CC=1O>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([C:17]3[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=3)=[CH:9][CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 692642-Chloro-5-nitrophenolHCID 3121834-Carboxyphenylboronic AcidHCID 8235603-(4-Bromophenyl)-5-methyl-1,2,4-oxadiazole

Product 1

HCID 218337574'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxylic acid

Procedure

The title compound was prepared from 4-(5-methyl-1,2,4-oxadiazol-3-yl)bromobenzene (0.58 g) and 4-boronobenzoic acid (0.4 g) as described in Description 15 as a white solid (0.64 g, 97%).

Sources & evidence

ORD record
ord-da702538d4184897a497a7d16f345759
Source dataset
uspto-grants-1998_09
Patent number
US05801170

Reaction notes

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