反应详情

温度

90 °C

4-Fluoro-2-methyl-nitrobenzene (2 g, 0.013 mol), 1,2,4-triazole (0.9 g, 0.013 mol), potassium carbonate (1.78 g, 0.013 mol) were dissolved in DMSO (50 ml) and stirred at 90° C. for 24 h under dry conditions. The yellow suspension was poured into water (150 ml), extracted (EtOAc), dried (Na2SO4) and evaporated under reduced pressure to afford an orange solid which was purified by flash column chromatography on silica eluting with n-pentane/ethyl acetate (50-100%) to afford a white solid (2.83 g 69%).

1. extractionextracted (EtOAc)
2. dry with materialdried (Na2SO4)
3. customevaporated under reduced pressure
4. customto afford an orange solid which
5. customwas purified by flash column chromatography on silica eluting with n-pentane/ethyl acetate (50-100%)
6. customto afford a white solid (2.83 g 69%)