4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzoic Acid → N-[3-(2-Diisopropylaminoethoxy)-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

HRID 2392680Notes

Reaction equation

HRID 2392680 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([CH3:13])[O:10][N:9]=2)[CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[CH:23]([N:26]([CH:39]([CH3:41])[CH3:40])[CH2:27][CH2:28][O:29][C:30]1[CH:31]=[C:32]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[NH2:33])([CH3:25])[CH3:24]>>[CH:39]([N:26]([CH:23]([CH3:24])[CH3:25])[CH2:27][CH2:28][O:29][C:30]1[CH:31]=[C:32]([NH:33][C:20]([C:17]2[CH:16]=[CH:15][C:14]([C:3]3[CH:4]=[CH:5][C:6]([C:8]4[N:12]=[C:11]([CH3:13])[O:10][N:9]=4)=[CH:7][C:2]=3[CH3:1])=[CH:19][CH:18]=2)=[O:21])[CH:34]=[CH:35][C:36]=1[O:37][CH3:38])([CH3:41])[CH3:40]

Participants

3

Reactant 2

HCID 111301684-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzoic AcidHCID 113576133-(2-Diisopropylaminoethoxy)-4-methoxyaniline

Product 1

HCID 18672736N-[3-(2-Diisopropylaminoethoxy)-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Procedure

The title compound was prepared from 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid (EP 0533268 A1) and 3-(2-diisopropylaminoethoxy)-4-methoxyaniline (D4) following a procedure similar to that described in Example 1 (27%) mp 130°-131° C.

Sources & evidence

ORD record
ord-6c1a9fe6c7df48c4b3fb8dd28175762d
Source dataset
uspto-grants-1998_09
Patent number
US05801170

Reaction notes

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