4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzoic Acid → N-[3-(2-Dimethylaminoethylthio)-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

HRID 2392690Notes

Reaction equation

HRID 2392690 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([CH3:13])[O:10][N:9]=2)[CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([S:32][CH2:33][CH2:34][N:35]([CH3:37])[CH3:36])[CH:25]=1>>[CH3:37][N:35]([CH3:36])[CH2:34][CH2:33][S:32][C:26]1[CH:25]=[C:24]([NH:23][C:20]([C:17]2[CH:16]=[CH:15][C:14]([C:3]3[CH:4]=[CH:5][C:6]([C:8]4[N:12]=[C:11]([CH3:13])[O:10][N:9]=4)=[CH:7][C:2]=3[CH3:1])=[CH:19][CH:18]=2)=[O:22])[CH:29]=[CH:28][C:27]=1[O:30][CH3:31]

Participants

3

Reactant 2

HCID 111301684-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzoic AcidHCID 189801014-Amino-2-(2-dimethylaminoethylthio)anisole

Product 1

HCID 18980133N-[3-(2-Dimethylaminoethylthio)-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Procedure

The title compound was prepared from 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid (EP 0533268 A1) and 4-amino-2-(2-dimethylaminoethylthio)anisole (D48) using a similar procedure to Example 1 (50%) mp 138°-9° C.

Sources & evidence

ORD record
ord-dbf53c67b0e647f5847c60a2595a18b1
Source dataset
uspto-grants-1998_09
Patent number
US05801170

Reaction notes

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