Potassium Bromide → HCID 18980361, compound

HRID 2392711Notes

Reaction equation

HRID 2392711 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=[C:4]([N+:21]([O-:23])=O)[CH:3]=1.[K+].[Br-]>CCO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[NH:9][C:10](=[O:20])[C:11]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[N+:21]2[O-:23]

Participants

4

Reactant 2

HCID 253877Potassium BromideHCID 53747438HCID 53747438, compound

Product 1

HCID 18980361HCID 18980361, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the procedure described in the preceding example by substituting 127 (8 mmol) for 125. Yield: 75%; mp 262°-264° C. (from EtOH); IR (KBr) 3439, 3204, 2934, 2841, 1696, 1682, 1663, 1609, 1362, 1308, 1262 and 1184 cm-1 ; 1H NMR (in DMSO-d6) δ3.79 (s, 3H), 6.99 (d, 2H, J=8.7 Hz), 7.50 (s, 1H), 7.74 (d, 2H, J=8.7 Hz), 8.28 (s, 1H), 12.48 (br.s, 1H, N--H); HPLC: 97%; HRMS Calcd for C15H10N2O3Cl2 : 336.0068. Found: 336.0068.

Sources & evidence

ORD record
ord-83d4f72e89224414945599d66fb127aa
Source dataset
uspto-grants-1998_09
Patent number
US05801183

Reaction notes

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