Potassium Bromide → HCID 18980374, compound

HRID 2392715Notes

Reaction equation

HRID 2392715 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10](=[O:25])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:13]=2)=[C:4]([N+:26]([O-:28])=O)[CH:3]=1.[K+].[Br-]>CCO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[NH:9][C:10](=[O:25])[C:11]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:13]=1)=[N+:26]2[O-:28]

Participants

4

Reactant 2

HCID 253877Potassium BromideHCID 67695702HCID 67695702, compound

Product 1

HCID 18980374HCID 18980374, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the general procedure described in Example 6 by substituting 8 mmol of 135 for 125. Yield: 53%; mp 258°-260° C. (from EtOH); IR (KBr) 3450, 3207, 3180, 3039, 1674, 1617, 1581, 1465, 1361, 1262, 1220 and 1149 cm-1 ; 1H NMR (in DMSO-d6) δ7.10 (m, 3H), 7.37 (m, 5H), 7.44 (s, 1H), 7.50 (s, 1H), 8.27 (s, 1H), 12.58 (br.s, 1H, N--H); HPLC: 98%; HRMS Calcd for C20H12N2O3Cl2 : 398.0225.

Sources & evidence

ORD record
ord-5324b6f8bac94726adc0b2c3fcb2ce1a
Source dataset
uspto-grants-1998_09
Patent number
US05801183

Reaction notes

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