3-Bromoanisole → HCID 18980486, compound

HRID 2392741Notes

Reaction equation

HRID 2392741 reaction equation
[ClH:1].[CH2:2]([O:5][CH:6]1[CH2:11][CH2:10][C:9](=[O:12])[CH:8]([CH2:13][N:14]([CH3:16])[CH3:15])[CH2:7]1)[CH:3]=[CH2:4].Br[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=1>>[ClH:1].[CH2:2]([O:5][CH:6]1[CH2:11][CH2:10][C:9]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)([OH:12])[CH:8]([CH2:13][N:14]([CH3:16])[CH3:15])[CH2:7]1)[CH:3]=[CH2:4]

Participants

3

Reactant 2

HCID 169713-BromoanisoleHCID 18980511HCID 18980511, compound

Product 1

HCID 18980486HCID 18980486, compoundYield 37%

Procedure

Base (13) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with 1:4 ether/diisopropyl ether via a silica gel column and was taken up in 1:1 2-butanone/ether. After adding trimethylchlorosilane/water, compound (10) was obtained in a yield of 37% theoretical.

Workup

  1. customThe base obtained
  2. customwas purified with 1:4 ether/diisopropyl ether via a silica gel column
  3. additionAfter adding trimethylchlorosilane/water

Sources & evidence

ORD record
ord-000dff36fe924baab08712cf5e4f3eb9
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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