Methyl Ethyl Ketone → 2-Dimethylaminomethyl-4-isobutoxy-cyclohexanone hydrochloride

HRID 2392743Notes

Reaction equation

[CH2:1]([O:5][CH:6]1[CH2:11][CH2:10][C:9](=[O:12])[CH2:8][CH2:7]1)[CH:2]([CH3:4])[CH3:3].[ClH:13].[CH3:14][NH:15][CH3:16].[CH3:17]C(=O)CC>>[ClH:13].[CH3:14][N:15]([CH2:17][CH:10]1[CH2:11][CH:6]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH2:7][CH2:8][C:9]1=[O:12])[CH3:16]

Participants

Reactant 3

HCID 6569Methyl Ethyl Ketone

HCID 10473Dimethylamine, hydrochloride

HCID 184137254-(2-Methylpropoxy)cyclohexan-1-one

Product 1

HCID 189805002-Dimethylaminomethyl-4-isobutoxy-cyclohexanone hydrochlorideYield 53%

Procedure

Compound (21) was reacted with dimethylamine hydrochloride corresponding to the conditions described in Example 10, step 3. The compound of formula (22) was obtained from 2-butanone in a yield of 53% theoretical.

Sources & evidence

ORD record: ord-7922502bbcb44e8d9dbee328294b4566
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05801201

Reaction notes

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