反应详情

9.5 g (50 mmole) 4-phenoxy-cyclohexanone (26), 0.765 g (25 mmole) paraformaldehyde and 2.08 g (25 mmole) dimethylamine hydrochloride were heated for 20 minutes in 17 ml acetic acid in an oil bath at a temperature of 105° C. Thereafter the solvent was distilled off under vacuum, the residue was treated twice with 2-butanone, and the 2-butanone was subsequently distilled off under vacuum. The salt obtained was taken up in 30 ml 2-butanone. 2.85 g of compound (27) (40% theoretical) were obtained.

1. distillationThereafter the solvent was distilled off under vacuum
2. additionthe residue was treated twice with 2-butanone
3. distillationthe 2-butanone was subsequently distilled off under vacuum
4. customThe salt obtained