192870-97-6 → HCID 18980462, compound

HRID 2392750Notes

Reaction equation

HRID 2392750 reaction equation
[ClH:1].[CH3:2][N:3]([CH2:5][CH:6]1[CH2:11][CH:10]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:9][CH2:8][C:7]1=[O:19])[CH3:4].Br[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH2:28][C:29]([CH3:31])=[CH2:30])[CH:22]=1>>[ClH:1].[CH3:4][N:3]([CH2:5][CH:6]1[CH2:11][CH:10]([O:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:9][CH2:8][C:7]1([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH2:28][C:29]([CH3:31])=[CH2:30])[CH:22]=1)[OH:19])[CH3:2]

Participants

3

Reactant 2

HCID 15816719192870-97-6HCID 18980453HCID 18980453, compound

Product 1

HCID 18980462HCID 18980462, compoundYield 51%

Procedure

The base of compound (27) was reacted with 1-bromo-3-(2-methyl-allyloxy)-benzene corresponding to the conditions described in Example 1. The base obtained was purified with ether via a silica gel column and was taken up in 2-butanone. After adding trimethylchlorosilane/water, compound (31) was obtained in a yield of 51% theoretical. melting point: 193° C.-195° C.

Workup

  1. customThe base obtained
  2. customwas purified with ether via a silica gel column
  3. additionAfter adding trimethylchlorosilane/water

Sources & evidence

ORD record
ord-567e1ae6289e4e6fa33cf391c613d585
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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