3-Methoxyphenol → HCID 18980452, compound

HRID 2392751Notes

Reaction equation

HRID 2392751 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[O:10]1[C:14]2([CH2:19][CH2:18][CH:17](OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:16][CH2:15]2)OCC1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[O:9][CH:17]1[CH2:18][CH2:19][C:14](=[O:10])[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 90073-MethoxyphenolHCID 5674891,4-Dioxaspiro[4.5]decan-8-ol, 8-(4-methylbenzenesulfonate)

Product 1

HCID 18980452HCID 18980452, compoundYield 57%

Procedure

3-methoxy-phenol was reacted with toluene-4-sulphonic acid-1,4-dioxa-spiro[4.5]dec-8-yl ester corresponding to the conditions described in Example 16, step 1. The crude product was subjected, without purification, to an acetal cleavage corresponding to the conditions described in Example 16, step 2. The ketone obtained was purified with diisopropyl ether on a silica gel column. Compound (33) was obtained in a yield of 57% theoretical.

Workup

  1. customThe crude product was subjected, without purification, to an acetal cleavage corresponding to the conditions

Sources & evidence

ORD record
ord-a1a8f401a7a34448bc50852f6f82c7c8
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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