HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyphenol → 4-(3-Methoxy-phenoxy)-cyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-ol, 8-(4-methylbenzenesulfonate) | HCID 567489 | — |
| Product | 4-(3-Methoxy-phenoxy)-cyclohexanone | HCID 18980452 | 57% |
Reaction Steps
3-methoxy-phenol was reacted with toluene-4-sulphonic acid-1,4-dioxa-spiro[4.5]dec-8-yl ester corresponding to the conditions described in Example 16, step 1. The crude product was subjected, without purification, to an acetal cleavage corresponding to the conditions described in Example 16, step 2. The ketone obtained was purified with diisopropyl ether on a silica gel column. Compound (33) was obtained in a yield of 57% theoretical.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05801201 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-a1a8f401a7a34448bc50852f6f82c7c8 |
| Source note | uspto-grants-1998_09 |