HCID 18980432, compound → HCID 18980472, compound

HRID 2392754Notes

Reaction equation

HRID 2392754 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2([OH:33])[CH2:20][CH2:19][CH:18]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=3)[CH2:17][CH:16]2[CH2:29][N:30]([CH3:32])[CH3:31])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[Cl:34]CCl.CCOCC>>[ClH:34].[CH3:31][N:30]([CH2:29][CH:16]1[CH2:17][CH:18]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=2)[CH2:19][CH2:20][C:15]1([C:11]1[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=1)[OH:33])[CH3:32]

Participants

3

Reactant 2

HCID 18980432HCID 18980432, compoundHCID 21881112Ethyl ether methylene chloride

Product 1

HCID 18980472HCID 18980472, compoundYield 56%

Procedure

Compound (43) was hydrogenated corresponding to the conditions described in Example 23, step 2. The product was then taken up in 1:1 dichloromethane/ether and tetramethylchlorosilane/water was added. After recrystallisation from 2-butanone/water, compound (39) was obtained in a yield of 56% theoretical.

Workup

  1. additionwas added
  2. customAfter recrystallisation from 2-butanone/water

Sources & evidence

ORD record
ord-040c6757c52d42b9a50b30e8a1f2fdc8
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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