1-Chloro-2-phenylethane → HCID 53837619, compound

HRID 2392756Notes

Reaction equation

HRID 2392756 reaction equation
Cl[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[O:10]1[C:14]2([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]2)OCC1>>[OH:10][C:14]1([CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:15][CH2:16][C:17](=[O:20])[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 2314961-Chloro-2-phenylethaneHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 53837619HCID 53837619, compoundYield 71%

Procedure

(2-chloroethyl)-benzene was reacted with 1,4-dioxa-spiro[4.5]decan-8-one corresponding to the conditions described in Example 24, step 1. The product was purified with 5:1 ether/n-hexane on a silica gel column. Compound (46) was obtained in a yield of 71% theoretical.

Workup

  1. customThe product was purified with 5:1 ether/n-hexane on a silica gel column

Sources & evidence

ORD record
ord-471e9eb3def34d97a98dce6d4f6eee7e
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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