反应详情

The base of compound (48) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified firstly with 7:1 ether/methanol via a silica gel column and subsequently via HPLC. It was taken up in 2-butanone and trimethylchlorosilane/water was added, with the addition of ether if necessary. Compound (45) was obtained in a yield of 40% theoretical.

1. customThe base obtained
2. customwas purified firstly with 7:1 ether/methanol via a silica gel column and subsequently via HPLC
3. additiontrimethylchlorosilane/water was added, with the addition of ether if necessary