3-Bromoanisole → (1RS,2RS,4SR)-2-dimethylaminomethyl-1-(3-methoxy-phenyl)-4-phenylethyl-cyclohexanol hydrochloride

Participants

Reaction Steps

The base of compound (48) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified firstly with 7:1 ether/methanol via a silica gel column and subsequently via HPLC. It was taken up in 2-butanone and trimethylchlorosilane/water was added, with the addition of ether if necessary. Compound (45) was obtained in a yield of 40% theoretical.

Provenance & Evidence