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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2392759Generated: October 30, 2026

1-(Benzyloxy)-3-bromobenzene → 1-(3-Benzyloxyphenyl)-2-dimethylaminomethyl-4-phenethyl-cyclohexanol

https://huagongshe.com/reaction/2392759

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Benzyloxy)-3-bromobenzeneHCID 2756638—
Reactant2-Dimethylaminomethyl-4-(phenethyl)-cyclohexanone hydrochlorideHCID 18980416—
Product1-(3-Benzyloxyphenyl)-2-dimethylaminomethyl-4-phenethyl-cyclohexanolHCID 1898050887%

Reaction Steps

The base of compound (48) was reacted with 1-bromo-3-benzyloxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with 6:1 ether/methanol via a silica gel column. Compound (50) was obtained in a yield of 87% theoretical.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05801201
Source datasetuspto-grants-1998_09
ORD IDord-1fbe2eb38c164f31991fd090afc5d87e
Source noteuspto-grants-1998_09