Sodium Carbonate → HCID 10471556, compound

HRID 2392852Notes

Reaction equation

HRID 2392852 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([S:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH2:14]([NH2:24])[C:15]1[CH:23]=[CH:22][C:21]2[O:20][CH2:19][O:18][C:17]=2[CH:16]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[CH2:19]1[O:20][C:21]2[CH:22]=[CH:23][C:15]([CH2:14][NH:24][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([S:12][CH3:13])[CH:10]=4)[N:5]=[CH:4][N:3]=3)=[CH:16][C:17]=2[O:18]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 75799Benzo-1,3-dioxole-5-methylamineHCID 103758454-Chloro-6-(methylthio)quinazoline

Product 1

HCID 10471556HCID 10471556, compoundYield 83.4%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4.12 g (0.0196 mol) of 4-chloro-6-methylthioquinazoline, 3.70 g (0.0245 mol) of piperonylamine and 3.50 g (0.0330 mol) of sodium carbonate were mixed with 100 ml of isopropyl alcohol. The obtained mixture was heated under reflux for 24 hours and distilled under a reduced pressure to remove the solvent. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane) and recrystallized from chloroform/n-hexane to give 5.32 g of the title compound as a pale-yellow crystal.

Workup

  1. temperatureThe obtained mixture was heated
  2. temperatureunder reflux for 24 hours
  3. distillationdistilled under a reduced pressure
  4. customto remove the solvent
  5. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane)
  6. customrecrystallized from chloroform/n-hexane

Sources & evidence

ORD record
ord-5e1687cc59c8481da97d9c856b14a438
Source dataset
uspto-grants-1998_09
Patent number
US05801180

Reaction notes

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