反应详情

A mixture comprising 1.00 g (2.86 mmol) of 4-(4-chloro-3-nitrobenzyl)amino-6-chloroquinazoline, 0.85 g of powdered iron, 10 ml of acetic acid and 50 ml of ethanol was heated under reflux for several hours and distilled under a reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (ethyl acetate/n-hexane) to give 0.91 g of the title compound as a pale-yellow crystal.

1. temperatureunder reflux for several hours
2. distillationdistilled under a reduced pressure
3. customto remove the solvent
4. customThe residue was purified by silica gel column chromatography (ethyl acetate/n-hexane)