Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 4-((1,3-Benzodioxol-5-ylmethyl)amino)-2,6-dichloro quinazoline | HCID 22339865 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18980296 | HCID 18980296 | 75.5% |
Reaction Steps
20 ml of N,N-dimethylformamide and 221 mg of sodium thiomethoxide were added to 1 g of 2,6-dichloro-4-(3,4-methylenedioxybenzyl)aminoquinazoline. The obtained mixture was stirred at 110° C. for one hour, neutralized with 1N hydrochloric acid and stirred at room temperature for one hour, followed by the addition of water. The crystals thus precipitated were recovered by filtration to give 780 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05801180 |
|---|
| Source dataset | uspto-grants-1998_09 |
|---|
| ORD ID | ord-d26a9e9c6ec848f68e693cb2337dc99d |
|---|
| Source note | uspto-grants-1998_09 |
|---|
