Hydrochloric Acid → HCID 18980296, compound

HRID 2392884Notes

Reaction equation

HRID 2392884 reaction equation
CN(C)C=O.[CH3:6][S-:7].[Na+].Cl[C:10]1[N:19]=[C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]3[O:28][CH2:29][O:30][C:24]=3[CH:23]=2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:31])[CH:16]=2)[N:11]=1.Cl>O>[CH3:6][S:7][C:10]1[N:19]=[C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]3[O:28][CH2:29][O:30][C:24]=3[CH:23]=2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:31])[CH:16]=2)[N:11]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 4378561Sodium methanethiolateHCID 223398654-((1,3-Benzodioxol-5-ylmethyl)amino)-2,6-dichloro quinazoline

Product 1

HCID 18980296HCID 18980296, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
110 °C

Procedure

20 ml of N,N-dimethylformamide and 221 mg of sodium thiomethoxide were added to 1 g of 2,6-dichloro-4-(3,4-methylenedioxybenzyl)aminoquinazoline. The obtained mixture was stirred at 110° C. for one hour, neutralized with 1N hydrochloric acid and stirred at room temperature for one hour, followed by the addition of water. The crystals thus precipitated were recovered by filtration to give 780 mg of the title compound.

Workup

  1. stirringstirred at room temperature for one hour
  2. customThe crystals thus precipitated
  3. filtrationwere recovered by filtration

Sources & evidence

ORD record
ord-d26a9e9c6ec848f68e693cb2337dc99d
Source dataset
uspto-grants-1998_09
Patent number
US05801180

Reaction notes

Loading…