反应详情

A mixture of 15.9 g (50 mmol) of methyl (R)-2-(4-(4-chlorobenzoyl)phenoxy)propionate, 25 g (220 mmol) of a 30% strength solution of hydrogen peroxide in water and 200 ml of formic acid was stirred at 35°-40° C. for 13 hours. The mixture was then stirred into a mixture of 0.5 l of methylene chloride and 2 l of water. The organic phase was separated off, dried over sodium sulfate and concentrated under reduced pressure. Yield: 69% (94-95% enantiomeric excess).

1. customThe organic phase was separated off
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated under reduced pressure