Hydrochloric Acid → Methyl (R)-2-(4-hydroxyphenoxy)propionate

Beteiligte Stoffe

Reaktionsschritte

A mixture of 45 g (189 mmol) of methyl (R)-2-(4-acetoxyphenoxy)propionate (enantiomeric excess 94-95%), 135 ml of methanol and 2.5 ml of methanol saturated with gaseous hydrogen chloride was refluxed for 5 h and subsequently concentrated. The crude product was purified by distillation at 140° C. under 0.1 mbar. Yield: 96% (94-95% enantiomeric excess).

Herkunft & Nachweise