反应详情

A mixture of 45 g (189 mmol) of methyl (R)-2-(4-acetoxyphenoxy)propionate (enantiomeric excess 94-95%), 135 ml of methanol and 2.5 ml of methanol saturated with gaseous hydrogen chloride was refluxed for 5 h and subsequently concentrated. The crude product was purified by distillation at 140° C. under 0.1 mbar. Yield: 96% (94-95% enantiomeric excess).

1. temperaturewas refluxed for 5 h
2. concentrationsubsequently concentrated
3. distillationThe crude product was purified by distillation at 140° C. under 0.1 mbar