Triethylamine → HCID 18977979, compound

HRID 2392994Notes

Reaction equation

HRID 2392994 reaction equation
C(N(CC)CC)C.[CH:8]1([C:11]2[O:15][N:14]=[CH:13][C:12]=2[C:16](=[O:29])[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[C:18]=2[S:25]([CH3:28])(=[O:27])=[O:26])[CH2:10][CH2:9]1>ClCCl>[C:13]([CH:12]([C:11]([CH:8]1[CH2:9][CH2:10]1)=[O:15])[C:16]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[C:18]=1[S:25]([CH3:28])(=[O:26])=[O:27])=[O:29])#[N:14]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 15452214HCID 15452214, compound

Product 1

HCID 18977979HCID 18977979, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Triethylamine (0.5 ml) was added to 5-cyclopropyl-4-(3,4-dichloro-2-methylsulphonylbenzoyl)isoxazole (1.0 g) in dichloromethane. The mixture was stirred at room temperature for 2.5 hours and evaporated to dryness. The residue was suspended in hydrochloric acid (2M) and was extracted with dichloromethane. The organic layer was washed with water, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness to give 2-cyano-3-cyclopropyl-1-(3,4-dichloro-2-methylsulphonylphenyl)propan-1,3-dione (COMPOUND 623) as a white solid, m.p. 88°-90° C.45

Workup

  1. customevaporated to dryness
  2. extractionwas extracted with dichloromethane
  3. washThe organic layer was washed with water
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-194968d31953454aa43997e50c6fc275
Source dataset
uspto-grants-1998_09
Patent number
US05804532

Reaction notes

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