反应详情

Triethylamine (1.78 g) was added to a stirred solution of 4,4-dimethyl-3-oxopentanenitrile (2.0 g) in dichloromethane and the mixture was stirred at room temperature for 2 hours. A solution of 2-chloro-4-methylsulphenylbenzoyl chloride (3.02 g) in dichloromethane was added and the mixture stirred at room temperature overnight. Acetone cyanohydrin (1.36 g) was added and the mixture stirred for 4 days, then filtered. The filtrate was washed with hydrochloric acid (2M), water, aqueous sodium bicarbonate solution, water, then dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue purified by column chromatography (hexane, ethyl acetate and acetic acid). The main fraction was washed with aqueous sodium hydroxide (2M), water, dried and evaporated to dryness to give 1-(2-chloro-4-methylsulphenylphenyl)-2-cyano-4,4-dimethylpentan-1,3-dione (COMPOUND 664, 0.16 g) as a white solid, m.p. 97°-99° C.

1. stirringthe mixture stirred at room temperature overnight
2. stirringthe mixture stirred for 4 days
3. filtrationfiltered
4. washThe filtrate was washed with hydrochloric acid (2M), water, aqueous sodium bicarbonate solution, water
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customThe filtrate was evaporated to dryness
8. customthe residue purified by column chromatography (hexane, ethyl acetate and acetic acid)
9. washThe main fraction was washed with aqueous sodium hydroxide (2M), water
10. customdried
11. customevaporated to dryness