反应详情

A mixture of 2-nitro-4-trifluoromethylbenzonitrile (8.64 g), thiophenol (4.4 g), potassium carbonate (6.9 g) in acetonitrile was heated at reflux for 4 hours. After cooling, the mixture was poured into water and extracted with dichloromethane. The organic extract was dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. The residue was triturated with hexane to give 2-phenylsulphenyl-4-trifluoromethylbenzonitrile as a white solid (9.5 g), m.p. 51° C.

1. temperaturewas heated
2. temperatureat reflux for 4 hours
3. temperatureAfter cooling
4. extractionextracted with dichloromethane
5. extractionThe organic extract
6. dry with materialwas dried over anhydrous sodium sulphate
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure
9. customThe residue was triturated with hexane