Hydrochloric Acid → HCID 53897031, compound

HRID 2393028Notes

Reaction equation

HRID 2393028 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9]CC(C)(C)N=2)=[C:4]([S:15][CH3:16])[C:3]=1[O:17][CH3:18].Cl.[OH2:20]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:9])=[O:20])=[C:4]([S:15][CH3:16])[C:3]=1[O:17][CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 54263053HCID 54263053, compound

Product 1

HCID 53897031HCID 53897031, compound

Procedure

A mixture of 2-[4-chloro-3-methoxy-2-(methylsulphenyl)phenyl]-4,4-dimethyloxazoline (9.0 g) and hydrochloric acid (5M) was stirred and heated at reflux for 5 hours. After cooling, the mixture was diluted with water and extracted with dichloromethane. It was dried (magnesium sulphate), filtered and the filtrate was evaporated to dryness to give 4-chloro-3-methoxy-2-(methylsulphenyl) benzoic acid as a white solid, m.p. 98°-99° C.

Workup

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureAfter cooling
  4. extractionextracted with dichloromethane
  5. dry with materialIt was dried (magnesium sulphate)
  6. filtrationfiltered
  7. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-49ec3109d7cc465f8a06f4421b1ddaff
Source dataset
uspto-grants-1998_09
Patent number
US05804532

Reaction notes

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