m-Chloroperbenzoic acid → HCID 18977935, compound

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Reaction Steps

3-Chloroperbenzoic acid (about 50%, 2.5 g) was added to a solution of 5-cyclopropyl-4-(4-methyl-3-methylsulphenylbenzoyl)isoxazole (0.8 g) in dichloromethane and the mixture was stirred at room temperature overnight. An aqueous solution of sodium metabisulphite was added and the mixture was stirred for 20 minutes. The solid was filtered and the filtrate layers separated. The organic phase was washed with aqueous sodium acetate, brine, dried and filtered. The filtrate was evaporated and the residue triturated with ether and filtered to give 5-cyclopropyl-4-(4-methyl-3-methylsulphonylbenzoyl)isoxazole (0.65 g) as a white solid, m.p. 126.4°-127.7° C.

Provenance & Evidence