HCID 18978989, compound → HCID 178440622, compound

HRID 2393061Notes

Reaction equation

HRID 2393061 reaction equation
[CH2:1]([C:5]1[N:10]2[CH:11]([CH3:15])[C:12](=[O:14])[NH:13][C:9]2=[N:8][C:7](=[O:16])[C:6]=1[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]2[N:34](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:33]=[N:32][N:31]=2)=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH3:4]>CC(O)=O.O>[CH2:1]([C:5]1[N:10]2[CH:11]([CH3:15])[C:12](=[O:14])[NH:13][C:9]2=[N:8][C:7](=[O:16])[C:6]=1[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 18978989HCID 18978989, compound

Product 1

HCID 178440622HCID 178440622, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 0.2 g of 5-butyl-3-methyl-6-[[2'-[N-triphenylmethyl-(1H-tetrazol-5-yl)]biphenyl-4-yl]methyl]imidazo[1,2-a]pyrimidin-2,7-dione in 6 ml of AcOH and 2 ml of H2O is stirred at room temperature for 5 h, then is evaporated under reduced pressure. The residue is taken up into H2O, adjusted to pH 8 with diluted NaOH and extracted with AcOet. The aqueous phase is acidified to pH 5 with AcOH, to separate a solid which is filtered off and washed with H2O, to obtain 0.1 g of a white solid (80% yield, m.p=192°-194° C. dec.).

Workup

  1. customis evaporated under reduced pressure
  2. extractionextracted with AcOet
  3. customto separate a solid which
  4. filtrationis filtered off
  5. washwashed with H2O

Sources & evidence

ORD record
ord-363f04ec60c3457fa5ebd95afa61f35f
Source dataset
uspto-grants-1998_09
Patent number
US05804583

Reaction notes

Loading…