反应详情

Methyl 8-hydroxyquinoline-2-carboxylate (1.6 g), acetone (15 ml), potassium carbonate (1.3 g) and iodomethane (0.6 ml) were combined and stirred at room temperature for 48 h. The solvents were removed in vacuo and the resulting white residue suspended in water (25 ml) which was extracted with ethyl acetate (3×25 ml). The combined organic layers were dried (magnesium sulphate) and the solvents removed in vacuo to give the title compound as a white solid (1.72 g).

1. customThe solvents were removed in vacuo
2. extractionwas extracted with ethyl acetate (3×25 ml)
3. dry with materialThe combined organic layers were dried (magnesium sulphate)
4. customthe solvents removed in vacuo