HRID2393148

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(C(O)c2cc3c(cc2CCO[Si](C)(C)C(C)(C)C)OCO3)sc2ncccc12

HCID53873460

未命名化合物

PRODUCTS

生成物

结构：COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(C(O)c2cc3c(cc2CCO)OCO3)sc2ncccc12

HCID57235804

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

溶剂HCID962

Water

H2O

溶剂HCID8028

Tetrahydrofuran

C4H8O

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A solution of N-(4-chloro-3-methyl-5-isoxazolyl)-N-(methoxyethoxy-methyl)-2-[α-hydroxy-4,5-(methylenedioxy)-2-(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)benzyl]thieno[2,3-b]pyridine-3-sulfonamide (0.29 g, 0.40 mmoles) in acetic acid (3 ml), H2O (1 ml) and THF (1 ml) was stirred at ambient temperature for 18 hours, then diluted with EtOAc (100 ml) and washed with sat. NaHCO3 (2×200 ml). The organic layer was dried (MgSO4), filtered and concentrated to collect 0.23 g (94%) of the title compound as a yellow oil.

WORKUP

后处理

washwashed with sat. NaHCO3 (2×200 ml)
dry with materialThe organic layer was dried (MgSO4)
filtrationfiltered
concentrationconcentrated
customto collect 0.23 g (94%) of the title compound as a yellow oil

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e88c0fd118a4b25951363a538ddce61
来源数据集: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05804585
来源说明: uspto-grants-1998_09

反应 SMILES

[Cl:1][C:2]1[C:3]([CH3:47])=[N:4][O:5][C:6]=1[N:7]([CH2:41][O:42][CH2:43][CH2:44][O:45][CH3:46])[S:8]([C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][C:12]=1[CH:20]([OH:40])[C:21]1[CH:26]=[C:25]2[O:27][CH2:28][O:29][C:24]2=[CH:23][C:22]=1[CH2:30][CH2:31][O:32][Si](C(C)(C)C)(C)C)(=[O:10])=[O:9]>C(O)(=O)C.O.C1COCC1.CCOC(C)=O>[Cl:1][C:2]1[C:3]([CH3:47])=[N:4][O:5][C:6]=1[N:7]([CH2:41][O:42][CH2:43][CH2:44][O:45][CH3:46])[S:8]([C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][C:12]=1[CH:20]([OH:40])[C:21]1[CH:26]=[C:25]2[O:27][CH2:28][O:29][C:24]2=[CH:23][C:22]=1[CH2:30][CH2:31][OH:32])(=[O:9])=[O:10]