反应详情

A solution of coumarin-1 (11.0 g, 47.5 mmol) in ethyl acetate (150 mL) was treated with 10% Pd/C (100 mg) in a parr bottle. The suspension was then hydrogenated at 80 psi and 80° C. for 6 hours. The suspension was filtered through a bed of celite to remove the Pd/C, and the celite bed washed with warm ethyl acetate (100 mL). The filtrate was concentrated and dried under vacuo to yield 11.0 g (100%) of the 3,4-dihydrocoumarin (2) as an oil;

1. filtrationThe suspension was filtered through a bed of celite
2. customto remove the Pd/C
3. washthe celite bed washed with warm ethyl acetate (100 mL)
4. concentrationThe filtrate was concentrated
5. customdried under vacuo