Acetone → HCID 178481847, compound

HRID 2393243Notes

Reaction equation

HRID 2393243 reaction equation
CC(C)=O.[CH3:5][N:6]1[C:10]([OH:11])=[C:9]([C:12](=[O:29])[C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:15]([CH:23](OC)[O:24]C)[C:14]=2[Cl:28])[CH:8]=[N:7]1>Cl>[CH3:5][N:6]1[C:10]([OH:11])=[C:9]([C:12](=[O:29])[C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:15]([CH:23]=[O:24])[C:14]=2[Cl:28])[CH:8]=[N:7]1

Participants

4

Reactant 2

HCID 180AcetoneHCID 178499615HCID 178499615, compound

Product 1

HCID 178481847HCID 178481847, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To acetone in a volume of 40 ml, was dissolved 1-methyl-5-hydroxy-4-(2-chloro-4-methanesulfonyl- 3-dimethoxymethylbenzoyl)pyrazole in an amount of 1.8 g (4.7 mmol), and hydrochloric acid in an amount of 2 ml was then added to the resulting solution. The mixture was stirred for 1 hour under heating reflux, and the solvent therein was removed by distillation. Crystals precipitated was washed with ether to obtain 1-methyl-5-hydroxy-4-(2-chloro-4-methanesulfonyl-3-formylbenzoyl)pyrazole in an amount of 1.5 g. The melting point of this compound is in a range of from 140° to 142° C.

Workup

  1. additionwas then added to the resulting solution
  2. temperatureunder heating
  3. temperaturereflux
  4. customthe solvent therein was removed by distillation
  5. customCrystals precipitated
  6. washwas washed with ether

Sources & evidence

ORD record
ord-2f175389e1ea4df1ae2e2aeefcb7087d
Source dataset
uspto-grants-1998_09
Patent number
US05807806

Reaction notes

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