Water → HCID 18975605, compound

Participants

Reaction Steps

A mixture of methyl (4-chloro-2,6-dimethyl-5-pyrimidinyl)-acetate (5.0 g, 23 mmol), 1-phenyl-1H-pyrazol-3-on (3.73 g, 23 mmol), potassium carbonate (5,5 g, 40 mmol) in dimethylformamide (30 ml) is heated at +120° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-phenyl-1H-pyrazol-3-yloxy)-pyrimidin-5-yl]-acetate as a yellow oil.

Provenance & Evidence