Water → HCID 18975605, compound

HRID 2393333Notes

Reaction equation

HRID 2393333 reaction equation
Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6]([CH3:13])[N:5]=[C:4]([CH3:14])[N:3]=1.[C:15]1([N:21]2[CH:25]=[CH:24][C:23](=[O:26])[NH:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O.CCOCC>[CH3:14][C:4]1[N:5]=[C:6]([CH3:13])[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:2]([O:26][C:23]2[CH:24]=[CH:25][N:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:22]=2)[N:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 5947241008-79-3HCID 54017032HCID 54017032, compound

Product 1

HCID 18975605HCID 18975605, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of methyl (4-chloro-2,6-dimethyl-5-pyrimidinyl)-acetate (5.0 g, 23 mmol), 1-phenyl-1H-pyrazol-3-on (3.73 g, 23 mmol), potassium carbonate (5,5 g, 40 mmol) in dimethylformamide (30 ml) is heated at +120° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-phenyl-1H-pyrazol-3-yloxy)-pyrimidin-5-yl]-acetate as a yellow oil.

Workup

  1. temperatureis heated at +120° C. for 2 hours
  2. customdrying

Sources & evidence

ORD record
ord-bb3be277db9a46f0b81226ebe2c986f8
Source dataset
uspto-grants-1998_09
Patent number
US05807863

Reaction notes

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