Dimethylamine → HCID 18975608, compound

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Reaction Steps

A mixture of methyl (4,6-dichloro-2-methyl-pyrimidin-5-yl )-acetate (5.43 g, 23 mmol), 1-phenyl-1H-pyrazol-3-on (3.73 g, 23 mmol) and potassium carbonate (5.5 g, 40 mmol) in dimethylformamide (30 ml) is heated at +120° C. for 30 minutes. Addition of dimethylamine (10 ml of a 25% aqueous solution) at room temperature, stirring for 20 hours and workup gives the intermediate methyl 2-[2-methyl-4-dimethylamino-6-(1-phenyl-1H-pyrazol-3-yloxy)-pyrimidin-5-yl]-acetate as an oil.

Provenance & Evidence