Dimethylamine → HCID 18975608, compound

HRID 2393335Notes

Reaction equation

HRID 2393335 reaction equation
Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6](Cl)[N:5]=[C:4]([CH3:14])[N:3]=1.[C:15]1([N:21]2[CH:25]=[CH:24][C:23](=[O:26])[NH:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:33][NH:34][CH3:35]>CN(C)C=O>[CH3:14][C:4]1[N:5]=[C:6]([N:34]([CH3:35])[CH3:33])[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:2]([O:26][C:23]2[CH:24]=[CH:25][N:21]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:22]=2)[N:3]=1

Participants

6

Reactant 4

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 5947241008-79-3HCID 19071353HCID 19071353, compound

Product 1

HCID 18975608HCID 18975608, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of methyl (4,6-dichloro-2-methyl-pyrimidin-5-yl )-acetate (5.43 g, 23 mmol), 1-phenyl-1H-pyrazol-3-on (3.73 g, 23 mmol) and potassium carbonate (5.5 g, 40 mmol) in dimethylformamide (30 ml) is heated at +120° C. for 30 minutes. Addition of dimethylamine (10 ml of a 25% aqueous solution) at room temperature, stirring for 20 hours and workup gives the intermediate methyl 2-[2-methyl-4-dimethylamino-6-(1-phenyl-1H-pyrazol-3-yloxy)-pyrimidin-5-yl]-acetate as an oil.

Workup

  1. temperatureis heated at +120° C. for 30 minutes

Sources & evidence

ORD record
ord-34fe79f995b04fc0a57de8ec09d5ecfe
Source dataset
uspto-grants-1998_09
Patent number
US05807863

Reaction notes

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